FORMULATION, CHARACTERIZATION AND POTENTIAL HEALTH BENEFITS OF DOPED ZnO IN CALAMINE LOTION

Abstract

In this study, we report on the formulation, characterization and potential health benefits of doped ZnO in calamine lotion. Also, antibacterial activities of the calamine lotion towards Staphylococcus aureus and Pseudomonas aeruginosa were investigated. The nanoparticles were prepared using sol-gel (alginate) technique. The samples were characterized using X-ray Diffraction (XRD) for structural determination (Crystallinity), Energy Dispersive X-ray Fluorescence (EDXRF) for elemental composition and Fourier Transform Infrared (FTIR) spectrophotometer for the functional groups. of the Ag-doped Fe3O4 nanoparticles with and without alginate (control experiment) The XRD patterns were the estimated particle sizes of Cu-doped ZnO were 32.10 (alginated) and 26.10 nm (without alginate) while those of ZnO, 24.80 and 19.30 nm respectively, indicating that the alginated phases were of larger particle sizes. The XRD patterns of the ZnO phases showed broader peaks. The EDXRF results confirmed that doping was successful with minor percentages for the dopant. The FT-IR results showed absorption peaks to the corresponding vibrational bands present. The nanoparticles were further applied in calamine lotion production and the lotion was tested for its antibacterial susceptibility using conventional Kirby-Bauer Agar. The susceptibility results showed that the commercial and the sample calamine lotions were both susceptible for the treatment of E.coli and S. aureus with the alginated Cu-doped ZnO giving the best E.coli clearance of 27.0 mm and it is recommended for use in calamine lotion production.