THE PHYTOCHEMICAL SCREENING AND HYPOGLYCAEMIC EFFECT OF MIRACLE LEAF (Synsepalum dulcificum) EXTRACTS AND METFORMIN DRUG INBLOOD GLUCOSE LEVEL OF ALLOXAN – INDUCED DIABETIC LABORATORY RATS.

Abstract

The study was designed to evaluate the phytochemical composition. The hypoglycaemics effect of three Miracle leaf extracts which include: methanol, hexane and chloroform extract with metformin drug which is used for type 2 diabetic mellitus were investigated on laboratory rats that was induced with Alloxan. The results of phytochemical analysis revealed the presence of saponins, alkaloids, flavonoids, tannins, glycosides, cardiac glycosides, phenol, terpenoid and steroid. The results of the hypoglycaemic activity of Synsepalum dulcificum leave extract showed presence of significant P?0.05 hypoglycaemic activity in all Miracle leaf extracts compared with control group. The result also showed highly significant p?0.05 hypoglycaemic activity of hexane extract compared with metformin drug than other extracts after (3,6,9) hrs of the treatment. This indicates that the leaves extract of Synsepalum dulcificum is good in management of diabetic’s mellitus cases. This may be as a result of high concentrations of phytochemicals like alkaloids, flavonoids, glycosides, phenol and terpenoid in the leaf extract which have demonstrated significant antidiabetics potentials through diverse mechanisms, including inhibition of carbohydrate-digesting enzymes, enhancement of insulin secretion and modulation of glucose uptake and antioxidant activity. In conclusion, its uses in human are recommended, but at a regulated doses because of its efficacy as stated in this study.