SOLVENT-FREE PREPARATION AND ANTIMICROBIAL STUDIES OF METAL (II) COMPLEXES DERIVED FROM CLOXACILLIN

Authors

  • S. Jibril
  • B. A. Saje
  • I. Musa
  • D. Dahuwa
  • H. U. Maigari

DOI:

https://doi.org/10.46602/jcsn.v48i1.845

Abstract

The authors use an environmental friendly, solvent-free method to prepare metal (II) complexes of cloxacillin and to determine the activity of the complexes. The complexes are more active against the bacteria isolates than the free cloxacillin. The spectral studies showed the cloxacillin (ligand) as monobasic bidentate material that form a complex with metal ion through the carbonyl of amide and carboxylate groups of carboxylic acid, microanalysis results prove that the ligand to metal ratio is 2:1. The researchers recommend the use of solvent-free drugs in the manufacture of metal (II) complexes of active pharmaceutical ingredients to avoid the excessive use of solvents that cause global problems.

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Published

2023-02-28

How to Cite

Jibril, S. ., Saje, B. A. ., Musa, I. ., Dahuwa, D. ., & Maigari, H. U. . (2023). SOLVENT-FREE PREPARATION AND ANTIMICROBIAL STUDIES OF METAL (II) COMPLEXES DERIVED FROM CLOXACILLIN . Journal of Chemical Society of Nigeria, 48(1). https://doi.org/10.46602/jcsn.v48i1.845

Issue

Vol. 48 No. 1 (2023): J. Chem. Soc. Nigeria

Section

Articles

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Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution (CC-BY) 4.0 License that allows others to share the work with an acknowledgment of the work’s authorship and initial publication in this journal.