PRELIMINARY INVESTIGATION INTO THE ALPHA-AMYLASE INHIBITORY ACTIVITIES OF AGERATUM CONYZOIDES (LINN.) LEAF EXTRACTS

Authors

  • O.O. Olubomehin Department of Chemical Sciences, Olabisi Onabanjo University, Ago-Iwoye
  • O.O. Adeyemi
  • K.N. Awokoya

Abstract

Ageratum conyzoides (Linn.) is a plant that has been scientifically proven to have anti-hyperglycaemic effect amongst other medicinal uses. We therefore set out to investigate the leaves for possible alpha-amylase inhibitory activity. At 1 mg/mL, the crude extracts (hexane, ethyl acetate and methanol) gave 50.23%, 45.54% and 26.03% inhibition respectively which were all significantly different from the control at p < 0.05 and comparable to acarbose which gave an inhibition of 50.97%. The results of this study show that the leaves of A. conyzoides possess alpha-amylase inhibitory potential which is beneficial in treating type 2 diabetes as lowering postprandial hyperglycaemia is one of the treatment goals. Keywords: Ageratum conyzoides, alpha-amylase inhibition, hyperglycaemia, type 2 diabetes. 

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Published

2017-02-14

How to Cite

Olubomehin, O., Adeyemi, O., & Awokoya, K. (2017). PRELIMINARY INVESTIGATION INTO THE ALPHA-AMYLASE INHIBITORY ACTIVITIES OF AGERATUM CONYZOIDES (LINN.) LEAF EXTRACTS. Journal of Chemical Society of Nigeria, 41(2). Retrieved from http://www.journals.chemsociety.org.ng/index.php/jcsn/article/view/74

Issue

Vol. 41 No. 2 (2016)

Section

Articles

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Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution (CC-BY) 4.0 License that allows others to share the work with an acknowledgment of the work’s authorship and initial publication in this journal.