Synthesis and In Vitro Antibacterial Activity of Morpholine Derived Benzenesulphonamides

Authors

  • A. Ahmed
  • D.I. Ugwu
  • O. G. Simon
  • H. O. Oluwasola

DOI:

https://doi.org/10.46602/jcsn.v46i5.670

Abstract

This study investigated the synthesis of sulphonamide substituted derivatives of morpholine from appropriate benzenesuphonyl chlorides obtaining excellent yields of oily products. The structural elucidation was confirmed by 1H and 13C NMR spectral analysis. The synthesized compounds; 4(-phenylsulonphonyl)morpholine and N-(4-(4-Methylbenzene-1-sulphonyl)morpholine) were evaluated for their in vitro antibacterial activity against bacteria; B. subtilus, S. typhi and E. coli. Both compounds were moderately active against B. Subtilis, but had no inhibitive activity against E. coli. Whereas, N-(4-(4-Methylbenzene-1-sulphonyl)morpholine) was moderately active against S. typhi. The physiochemical properties of the synthesized compounds evaluated, revealed its’ potential for drugs.

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Published

2021-11-11

How to Cite

Ahmed, A., Ugwu, D. ., Simon, O. G. ., & Oluwasola , H. O. . (2021). Synthesis and In Vitro Antibacterial Activity of Morpholine Derived Benzenesulphonamides . Journal of Chemical Society of Nigeria, 46(5). https://doi.org/10.46602/jcsn.v46i5.670

Issue

Vol. 46 No. 5 (2021): J. Chem. Soc. Nigeria

Section

Articles

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Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution (CC-BY) 4.0 License that allows others to share the work with an acknowledgment of the work’s authorship and initial publication in this journal.