SPECTROSCOPIC AND ANTIBACTERIAL STUDIES OF SOME NITRO-SUBSTITUTED N-(BENZOYLCARBAMOTHIOYL) AMINO ACIDS: THE CRYSTAL STRUCTURE OF N-(3-NITRO-BENZOYLCARBAMOTHIOYL)-GLYCINE

Authors

  • M. Fayomi Omotola
  • R. Sha’Ato
  • A. Wuana
  • O. Igoli John
  • Vashen Moodley
  • E. Van Zy Werner

Abstract

A series of nitro-substituted N-(benzoylcarbamothioyl)-amino acids (1-4) was synthesized by condensing 3- or 4-nitro-benzoyl isothiocyanate with amino acids (glycine and histidine). These compounds were characterized by HNMR, CNMR, FTIR, and MS. N-(3-nitro- benzoylcarbamothioyl)-glycine was also characterized by single crystal X-ray diffraction study. The compound crystallizes in triclinic space group P-1 with Z=2, a = 3.9354(4) Å, b= 12.6015(14) Å, c = 16.8149(16) Å, α = 71.451(5)°, β = 88.933(3)°, γ = 82.720(3)°. The preliminary antibacterial tests of the compounds gave good activity.

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Published

2018-04-18

How to Cite

Omotola, M. F., Sha’Ato, R., Wuana, A., John, O. I., Moodley, V., & Werner, E. V. Z. (2018). SPECTROSCOPIC AND ANTIBACTERIAL STUDIES OF SOME NITRO-SUBSTITUTED N-(BENZOYLCARBAMOTHIOYL) AMINO ACIDS: THE CRYSTAL STRUCTURE OF N-(3-NITRO-BENZOYLCARBAMOTHIOYL)-GLYCINE. Journal of Chemical Society of Nigeria, 43(2). Retrieved from http://www.journals.chemsociety.org.ng/index.php/jcsn/article/view/167

Issue

Vol. 43 No. 2 (2018)

Section

Articles

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